Subject(s)
Adolescent , Adult , Antibodies, Bacterial/blood , Child , Child, Preschool , Humans , Immunoglobulin G/blood , India , Paratyphoid Fever/epidemiology , Population Surveillance , Salmonella typhi/immunology , Treatment Outcome , Typhoid Fever/epidemiology , Typhoid Fever/immunology , Typhoid Fever/prevention & control , Typhoid-Paratyphoid Vaccines/immunologySubject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Disease Outbreaks/statistics & numerical data , Humans , Incidence , India/epidemiology , Infant , Infant, Newborn , Middle Aged , Paratyphoid Fever/epidemiology , Salmonella paratyphi A/immunology , Seroepidemiologic Studies , Typhoid-Paratyphoid Vaccines/immunologySubject(s)
Humans , Typhoid Fever/prevention & control , Typhoid-Paratyphoid Vaccines/immunology , Antibody Formation , Salmonella paratyphi A/immunology , Salmonella typhi/immunology , Treatment Outcome , Typhoid-Paratyphoid Vaccines/administration & dosage , Typhoid-Paratyphoid Vaccines , Typhoid-Paratyphoid Vaccines/pharmacologyABSTRACT
The specific immune responses to Salmonella typhi were investigated in 131 patients suffering from typhoid fever and 34 healthy individuals after TAB vaccination. A proportion of individuals failed to develop either specific humoral or cell mediated immune responses. About 5 per cent of the patients with natural infection and nearly 9 per cent of the vaccine recipients failed to develop both the responses. Frequent reinfection and carrier state, and lack of absolute protection following TAB vaccination could be due to the inability of a proportion of naturally infected and TAB vaccinated individuals to mount sufficient specific immune responses, due to the same mechanism.
Subject(s)
Adolescent , Adult , Antibodies, Bacterial/biosynthesis , Child , Female , Humans , Immunity, Cellular , Male , Salmonella typhi/immunology , Typhoid Fever/immunology , Typhoid-Paratyphoid Vaccines/immunologyABSTRACT
Anticorpos contra o antígeno comum de enterobactérias (ECA) bem como contra os antígenos somáticos (O) e flagelar (H) de Salmonella typhi foram investigados no soro de recrutas do sexo masculino, após a vacinaçäo. Näo foi detectada resposta humoral para ECA. Os soros obtidos antes da vacinaçäo mostraram hemaglutininas para ECA acompanhando a presença de aglutininas para o antígeno H, ao contrário do que se observou em relaçäo ao antígeno O. Discutem-se os resultados quanto ao possível mecanismo da imunoproteçäo da febre tifóide